According to an article published in The Journal Allergy and Clinical Immunology, human basophils do not have mannan receptors.
Basophils participate in allergic reactions and the absence of these receptors would avoid the risk of activation of these cells with mannan-conjugated vaccines (Sirvent et al-Manzano et al). These new vaccines have been designed by INMUNOTEK.
Human basophils may not undergo modulation by DC-SIGN and mannose receptor–targeting immunotherapies due to absence of receptors
Mrinmoy Das, Caroline Galeotti, Emmanuel Stephen-Victor, Anupama Karnam, Srini V. Kaveri, Jagadeesh Bayry
Institut National de la Santé et de la Recherche Médicale Unité 1138, Paris, France
Sorbonne Universités, UPMC Univ Paris 06, UMR S 1138, Paris, France
Centre de Recherche des Cordeliers, Equipe-Immunopathologie et immuno-intervention thérapeutique, Paris, France
Université Paris Descartes, Sorbonne Paris Cité, UMR S 1138, Paris, France
Journal Allergy and Clinical Immunology, 2017 (in press)