07/2016. Editorial article

An editorial article has appeared in The Journal of Allergy and Clinical Immunology on the novel allergoids conjugated with mannan developed by INMUNOTEK. 

Dendritic cell targeting using C-type lectins for the improvement of allergen immunotherapy

by Stefan Schülke, PhD, Stefan Vieths, PhD. Paul-Ehrlich-Institut, Langen, Hessen, Germany

In this editorial the authors remark the immunomodulating properties of the novel allergoid-mannan glycoconjugates and their potential impact for the development of novel vaccines for allergy immunotherapy.

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Figure 1: Proposed mechanism of immune modulation by mannan-conjugated allergoids. MR: mannose receptor, DC-SIGN: dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin, Th0: naive T cell, PD-1: programmed cell death protein 1, PD-L1: programmed death-ligand 1.

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J Allergy Clin Immunol. Volume 138, Issue 2, Pages 568–570 (2016). Figure with reuse permission 3984920602821