07/2018. Mosquitoes-Mites Crossreactivity

A new study highlighting the cross-reactivity between mosquitoes and mites has been published in the scientific journal Clinical and Experimental Allergy

Mosquito allergy is frequent in certain geographic areas that, in turn, have a high prevalence of allergy to dust mites.

The results of this study indicate that a protein shared by mosquitoes and mites, tropomyosin, is responsible for cross-reactivity at both humoral (antibodies) and cellular levels. These results reinforce the interesting possibility that patients allergic to mites may have allergic reactions to mosquitoes by cross-reactivity mechanisms and vice versa.

The study has had the collaboration of INMUNOTEK.

Title: Tropomyosins in mosquito and house dust mite cross-react at the humoral and cellular level.

Cantillo JF(1,2), Puerta L(2), Fernandez-Caldas E(3,4), Subiza JL(3), Soria I(3), Wöhrl S(5), Ebner C(6), Keller W(7), Resch-Marat Y(8), Vrtala S(8), Bohle B(8).

1 Complutense University of Madrid, Madrid, Spain.
2 Institute for Immunological Research/University of Cartagena, Cartagena, Colombia.
3 Inmunotek S.L., Alcalá de Henares, Spain.
4 University of South Florida College of Medicine, Tampa, Florida.
5 Floridsdorf Allergy Center (FAZ), Vienna, Austria.
6 Allergy Clinic Reumannplatz, Vienna, Austria.
7 Division of Structural Biology, Institute of Molecular Biosciences, BioTechMed University of Graz, Graz, Austria.
8 Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.

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Related studies:

Cantillo JF, Puerta L, Puchalska P, Lafosse-Marin S, Subiza JL, Fernandez-Caldas E. Allergenome characterization of the mosquito Aedes aegypti. Allergy 2017. 72(10):1499-1509

Cantillo JF, Puerta L, Lafosse-Marin S, Subiza JL, Caraballo L, Fernandez-Caldas E. Allergens involved in the cross-reactivity of Aedes aegypti with other arthropods. Ann Allergy Asthma Immunol 2017. 118(6):710-718

Cantillo JF, Puerta L, Lafosse-Marin S, Subiza JL, Caraballo L, Fernandez-Caldas E. Identification and Characterization of IgE-Binding Tropomyosins in Aedes aegypti. Int Arch Allergy Immunol 2016;170(1):46-56.

Lopez-Matas MA, Iraola V, Moya R, Vailes LD, Pomes A, Boquete M, Fernandez-Caldas E,  Arlian LG, Chapman M, Carnés J. Cloning and characterization of tropomyosin from the mite Chortoglyphus arcuatus. Molecular immunology 2015;68:634-40.

Cantillo JF, Fernandez-Caldas E, Puerta L. Immunological aspects of the immune response induced by mosquito allergens. Int Arch Allergy Immunol 2014;165(4):271-82.

Fernandez-Caldas E, Puerta L, Caraballo L. Mites and allergy. Chem Immunol Allergy 2014;100:234-42.