MV130 (Bactek) is a sublingual preparation composed of inactivated bacteria selected by INMUNOTEK and designed to prevent recurrent respiratory infections. This study analyzes the uptake of MV130 bacteria by mesenchymal stem cells from the oral mucosa in mice and the effect of these bacteria on the function of human mesenchymal stem cells.
The results of this research indicate that mesenchymal stem cells are very effective in capturing these bacteria, where they are stored as a reservoir, to later transfer them to the (dendritic) cells responsible for initiating an immune response. In addition, the functionality of the mesenchymal stem cells is modified towards an initial pro-inflammatory activity and an anti-inflammatory activity in a second stage.
This research has been carried out under the co-direction of Prof. Ángeles Vicente and Dr. Jaris Valencia of the Department of Cell Biology, Faculty of Medicine, Complutense University of Madrid, with the collaboration of INMUNOTEK.