10/2019. Aluminum hydroxide and allergoids coupled to mannan
Allergoids coupled to nonoxidized mannan induce tolerogenic effects on dendritic cells. Such effects are inhibited by aluminum hydroxide, a common adjuvant used in allergen vaccines. This is described, as well as the mechanisms involved, in a recent study in Allergy.
This research, led by prof. Oscar Palomares (School of Chemistry, Complutense University of Madrid) with the collaboration of INMUNOTEK, highlights the important role of certain metabolic pathways of dendritic cells (DC) activated by allergoid-mannan conjugates for these cells to acquire tolerogenic properties. These pathways are inhibited by aluminum hydroxide, so the ability of DC to induce tolerance to conjugated allergens is also inhibited.
