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MV130 confers protection by inducing trained immunity

Results published in Cell Reports show that MV130 protects against respiratory viral infections by inducing Trained Immunity. This type of immunity generates memory and depends on the “training” of Innate Immune System cells. Trained immunity involves epigenetic and metabolic changes that make trained cells more effective against infections, including viral infections.

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CIEGE 2021 Seal for Business Excellence

INMUNOTEK obtains the CIEGE Seal for excellence in business management for the third consecutive year granted by Informa-ElEconomista. This Seal certifies excellent management over 57 indicators from 10 categories: solvency, profitability, growth, employment, internationalization, corporate social responsibility, customer satisfaction, innovation, commercial risk management and digitization.

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MV130 protects and boosts vaccines against SARS-CoV-2

According to the results published in Frontiers in Immunology, MV130 protects against experimental infection with SARS-CoV-2 in hACE2 transgenic mice. In addition, pretreatment with MV130 is shown to enhance the immunogenicity of candidate COVID-19 vaccines directed against viral protein S, enhancing both antibody and cell-specific responses.

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INMUNOTEK listed in CEPYME500 – 2021

INMUNOTEK has once again been awarded the CEPYME500 seal in its 2021 edition, which recognizes the 500 leading Spanish companies in business growth, both for their results and their ability to generate added value, employment, innovation and international projection. This is the third year that INMUNOTEK has received this distinguished seal.

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Allergoid-mannan conjugates on macrophages

Allergy publishes a study showing that allergoid-mannan conjugates confer tolerogenic properties to human macrophages. These cells have been described to play a relevant role in the induction of allergen-specific tolerance in sublingual immunotherapy models, so this study may help to better understand the immunological mechanisms of allergy vaccines based on these glycoconjugates.

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MV140 results in recurrent UTIs

The results of a clinical trial with MV140 in women suffering from recurrent urinary tract infections (UTI) have been presented at the ICS21 (International Continence Society) congress, as well as at the BAUS21 (British Association of Urological Surgeon), EAU21 (European Association of Urology) and AUA21 (American Urological Association). The study (phase III) has been carried out in several centers in Spain and the United Kingdom, including 240 patients in the active group and placebo.

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MV140 and autovaccines against rUTIs in elderly patients

According to a study published in Vaccine on a population of elderly people with recurrent urinary tract infections, prophylactic treatment with MV140 or with autovaccines made from a urine sample reduces the frequency of infections and improves the patients’ quality of life. Comparatively, treatment with MV140 was superior to that obtained with autovaccines.

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MV130 in the prevention of exacerbations in COPD

The first results with MV130 in COPD patients have been presented at the European Respiratory Society (ERS) congress, showing its efficacy in reducing the number and intensity of exacerbations associated with this disease. The phase 3 study has been conducted in 7 hospitals including 198 patients that were followed during 18 months.

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Peach tree pollen allergy and peach tolerance

According to a study published in PLOS One, allergic patients with respiratory symptoms to peach tree pollen through their sensitization by Pru p 9 can tolerate the consumption of this fruit even if they are sensitized by Pru p 3, the main peach fruit allergen. This study, coordinated by Dr. Miguel Blanca, has been performed with the contribution of INMUNOTEK.

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AJRCCM publishes MV130 study

AJRCCM publishes in its August issue the results of the efficacy of MV130 in the prevention of recurrent wheezing attacks in young children. This is a randomized, double-blind, placebo-controlled phase 3 clinical trial conducted in two hospitals in Spain. The results are highlighted in an Editorial, which points out its importance as a new therapeutic option for the prevention of these processes and the implication of innate immune training as a possible mechanism of action.