10/2018. A pilot study in dogs with atopic dermatitis
It has been published in Veterinary Dermatology a clinical study with a novel vaccine for the treatment of canine atopic dermatitis developed by INMUNOTEK.
Canine atopic dermatitis is an allergic disease caused by sensitization to different allergens including mites. It can be treated by specific allergen immunotherapy. This study assess for the first time a vaccine consisting of polymers of mite allergens (D. farinae) conjugated with mannan derived from Saccharomyces cerevisiae. These glyco-conjugates are hypoallergenic and target dendritic cells (the cells of the immune system that initiate the immune response). The results of this trial are encouraging for the new preparation since they indicate a rapid clinical improvement with a reduced number of doses without safety concerns.
Related bibliography:
Manzano AI, Javier Cañada F, Cases B, Sirvent S, Soria I, Palomares O, Fernández-Caldas E, Casanovas M, Jiménez-Barbero J, Subiza JL. Glycoconj J. 2016 Feb;33(1):93-101. doi: 10.1007/s10719-015-9640-4. Epub 2015 Nov 25.
Sirvent S, Soria I, Cirauqui C, Cases B, Manzano AI, Diez-Rivero CM, Reche PA, López-Relaño J, Martínez-Naves E, Cañada FJ, Jiménez-Barbero J, Subiza J, Casanovas M, Fernández-Caldas E, Subiza JL, Palomares O. J Allergy Clin Immunol. 2016 Aug;138(2):558-567.e11. doi: 10.1016/j.jaci.2016.02.029. Epub 2016 Apr 13
Dendritic cell targeting with C-type lectins for improvement of allergen immunotherapy.
Schülke S, Vieths S. J Allergy Clin Immunol. 2016 Aug;138(2):568-70. doi: 10.1016/j.jaci.2016.06.006. Epub 2016 Jun 23.
Das M, Galeotti C, Stephen-Victor E, Karnam A, Kaveri SV, Bayry J. J Allergy Clin Immunol. 2017 Apr;139(4):1403-1404.e1. doi: 10.1016/j.jaci.2016.09.062. Epub 2017 Jan 11.
Soria I, Alvarez J, Manzano AI, López-Relaño J, Cases B, Mas-Fontao A, Cañada FJ, Fernández-Caldas E, Casanovas M, Jiménez-Barbero J, Palomares O, Viñals-Flórez LM, Subiza JL. Vet Immunol Immunopathol. 2017 Aug;190:65-72. doi: 10.1016/j.vetimm.2017.07.004. Epub 2017 Jul 23.
Soria I, López-Relaño J, Viñuela M, Tudela JI, Angelina A, Benito-Villalvilla C, Díez-Rivero CM, Cases B, Manzano AI, Fernández-Caldas E, Casanovas M, Palomares O, Subiza JL. Allergy. 2018 Apr;73(4):875-884. doi: 10.1111/all.13396. Epub 2018 Jan 31.
Novel vaccines targeting dendritic cells by coupling allergoids to mannan.
Benito-Villalvilla, C., Soria, I., Subiza, J.L. et al. Allergo J Int (2018). https://doi.org/10.1007/s40629-018-0069-8