07/2019. Immunomodulation by oral epithelial cells

The oral mucosa is subject to a constant exposure of foreign substances such as food and microorganisms that make up its flora. Understanding the mechanisms that operate to avoid inflammatory reactions has been one of the objectives of the work recently published in Frontiers in Immunology.

This research work, led by Prof. Pedro Reche (School of Medicine, Complutense University of Madrid), highlights the important regulatory role of epithelial cells in the oral cavity. These cells were shown to prevent the full maturation of dendritic cells (DC)  while exert a strong suppressor effect on T cells. As a stimulus for DC activation and maturation, a cocktail of bacteria (MV130) provided by INMUNOTEK was used. The activation pathways induced by MV130 on DC were known from previous studies.