Manzano AI, Javier Cañada F, Cases B, Sirvent S, Soria I, Palomares O, Fernández-Caldas E, Casanovas M, Jiménez-Barbero J, Subiza JL. Structural studies of novel glycoconjugates from polymerized allergens (allergoids) and mannans as allergy vaccines. Glycoconj J. 2016 Feb;33(1):93-101.
Sirvent S, Soria I, Cirauqui C, Cases B, Manzano AI, Diez-Rivero CM, Reche PA, López-Relaño J, Martínez-Naves E, Cañada FJ, Jiménez-Barbero J, Subiza J, Casanovas M, Fernández-Caldas E, Subiza JL, Palomares O. Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1. J Allergy Clin Immunol. 2016 Aug;138(2):558-567.e11.
Soria I, Alvarez J, Manzano AI, López-Relaño J, Cases B, Mas-Fontao A, Cañada FJ, Fernández-Caldas E, Casanovas M, Jiménez-Barbero J, Palomares O, Viñals-Flórez LM, Subiza JL. Mite allergoids coupled to nonoxidized mannan from Saccharomyces cerevisae efficiently target canine dendritic cells for novel allergy immunotherapy in veterinary medicine. Vet Immunol Immunopathol. 2017 Aug;190:65-72.
Soria I, López-Relaño J, Viñuela M, Tudela JI, Angelina A, Benito-Villalvilla C, Díez-Rivero CM, Cases B, Manzano AI, Fernández-Caldas E, Casanovas M, Palomares O, Subiza JL. Oral myeloid cells uptake allergoids coupled to mannan driving Th1/Treg responses upon sublingual delivery in mice. Allergy. 2018 Apr;73(4):875-884.
Benito-Villalvilla, C., Soria, I., Subiza, J.L. et al. Novel vaccines targeting dendritic cells by coupling allergoids to mannan. Allergo J Int 2018; 27, 256–262.
González JL, Zalve V, Fernández-Caldas E, Cases B, Subiza JL, Casanovas M. A pilot study of immunotherapy in dogs with atopic dermatitis using a mannan-Dermatophagoides farinae allergoid targeting dendritic cells. Vet Dermatol. 2018 Oct;29(5):449-e152.
Benito-Villalvilla C, Pérez-Diego M, Subiza JL, Palomares O. Allergoid-mannan conjugates imprint tolerogenic features in human macrophages. Allergy. 2022 Jan;77(1):320-323.
Benito-Villalvilla C, Pérez-Diego M, Angelina A, Kisand K, Rebane A, Subiza JL, Palomares O. Allergoid-mannan conjugates reprogram monocytes into tolerogenic dendritic cells via epigenetic and metabolic rewiring. J Allergy Clin Immunol. 2022 Jan;149(1):212-222.e9.
Nieto A, Mazón Á, Nieto M, Ibáñez E, Jang DT, Calaforra S, Alba P, Pérez-Francés C, Llusar R, Montoro J, de Mateo A, Alamar R, El-Qutob D, Fernández J, Moral L, Toral T, Antón M, Andreu C, Ferrer Á, Flores IM, Cerdá N, Del Pozo S, Caballero R, Subiza JL, Casanovas M. First-in-human phase 2 trial with mite allergoids coupled to mannan in subcutaneous and sublingual immunotherapy. Allergy. 2022 Oct;77(10):3096-3107.
Ojeda P, Barjau MC, Subiza J, Moreno A, Ojeda I, Solano E, Alonso A, Caballero R, Del Pozo S, Gómez-Perosanz M, Sánchez-Trincado JL, Benito-Villalvilla C, Angelina A, Soria I, Reche PA, Palomares O, Subiza JL, Casanovas M. Grass pollen allergoids conjugated with mannan for subcutaneous and sublingual immunotherapy: a dose-finding study. Front Immunol. 2024 Jun 26;15:1431351.
Del Pozo S, Wahrhusen N, Pfaar O, Raskopf E, Rybachuk A, Acikel C, Sahin H, Allekotte S, Subiza JL, Casanovas M, Cuevas M, Mösges R. Clinical Efficacy of One Short Course of Mannan-Conjugated Birch Pollen Allergoid Immunotherapy: A Comparative Evaluation After Prior Placebo Treatment. J Clin Med. 2025 Dec 3;14(23):8565.
Subiza J, Feliú A, Subiza JL, Uhlig J, Fernández-Caldas E. Cluster immunotherapy with a glutaraldehyde-modified mixture of grasses results in an improvement in specific nasal provocation tests in less than 2.5 months of treatment. Clin Exp Allergy. 2008 Jun;38(6):987-94
Cardona-Villa R, Uribe-Garcia S, Calvo-Betancur VD, Cantillo JF, Fernández-Caldas E. Efficacy and safety of subcutaneous immunotherapy with a mixture of glutaraldehyde-modified extracts of Dermatophagoides pteronyssinus, Dermatophagoides farinae, and Blomia tropicalis. World Allergy Organ J. 2022 Sep 8;15(9):100692
Sánchez J, Alvarez L, García E. Real-world study: drug reduction in children with allergic rhinitis and asthma receiving immunotherapy. Immunotherapy. 2023 Mar;15(4):253-266.
Cardona-Villa R, Del Pozo S, Uribe-García S, Calvo-Betancur VD, Fernández-Caldas E, Sánchez J. Clinical outcomes of allergen immunotherapy in children in Latin America: Treatment with polymerized allergen extracts of Dermatophagoides pteronyssinus and Dermatophagoides farinae. World Allergy Organ J. 2025 Aug 7;18(8):101094.
Torres-Borrego J, Marín López LP, Castañeda-Mendieta R, Burgos AM. Effectiveness and safety of immunotherapy with a mixture of polymerized allergen extracts of Alternaria alternata and olea europaea in children. Allergol Immunopathol (Madr). 2026 Jan 1;54(1):139-144.
Somoza ML, et al. Sensitisation to Pollen Allergens in Children and Adolescents of Different Ancestry Born and Living in the Same Area. J Asthma Allergy. 2022 Sep 26;15:1359-1367
González-Pérez R, Poza-Guedes P, Pineda F, Galán T, Mederos-Luis E, Abel-Fernández E, Martínez MJ, Sánchez-Machín I. Molecular Mapping of Allergen Exposome among Different Atopic Phenotypes. Int J Mol Sci. 2023 Jun 21;24(13):10467.
Nieto A, Abel-Fernández E, Pineda, F, Nieto M. 360º approach to the paediatric patient with mite allergy. From scientific evidence to clinical practice. Front Allergy. 2024 Feb 6;5:1298816.
Carballada González F, Abel-Fernández E, González Guzmán LA, Pineda de la Losa F. Component-Based Assessment of the Main Allergens in Honeybee Venom in a Spanish Allergic Population. J Investig Allergol Clin Immunol. 2025 Jun 2;35(3):237-238.
Tudela JI, Soria I, Abel-Fernández E, Cantillo JF, Fernández-Caldas E, Subiza JL, Iborra S. Polymerised mite allergoids with glutaraldehyde reduce proteolytic activity and enhance the stability of allergen mixtures: a proof of concept with grass mixtures. Front Allergy. 2025 Feb 25;6:1557650.
Abel-Fernández E, Fernández-Caldas E, Iborra S. Characterisation of Alternaria alternata Allergoids: Evaluation of the Stability of Grass Pollen Allergen Extracts Mixed with Alternaria alternata Allergoids. J Fungi (Basel). 2025 Feb 25;11(3):181.
Calderón-Llosa OM, Galván CA, Martínez MJ, González-Pérez R, Abel-Fernández E, Pineda F. Exploring Molecular Responses to Aeroallergens in Respiratory Allergy Across Six Locations in Peru. Allergies. 2025; 5(3):23
Galván CA, Durán R, Galán T, Abel-Fernández E, Canal-Solis K, González-Pérez R, Pineda F. Patterns of Immunoglobulin E-Mediated Molecule Sensitization across Four Peruvian Cities: Exploring Relationships with Regional Climate Classifications. Int Arch Allergy Immunol. 2026;187(3):261-272
González-Pérez R, et al. Precision Medicine in Allergic Rhinitis and Conjunctivitis: Integrative Molecular Mapping of the Allergic Exposome in Spain (EXPOMOL Study). J Investig Allergol Clin Immunol. 2026 Feb 13:0.
